69 articles - From Friday Oct 31 2025 to Friday Nov 07 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Hepatology |
|---|
| AASLD/IDSA Practice Guideline on treatment of chronic hepatitis B.
This evidence-based guideline provides updated recommendations to optimize the care of persons with CHB. |
| Commentary - AASLD Practice Guideline on treatment of chronic hepatitis B (2025 Update). |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
| Meta-Analysis: Improvement of Bowel Urgency With Advanced Therapies for Inflammatory Bowel Disease.
Advanced IBD therapies with different mechanisms of action produce rapid and sustained improvement in BU. The degree of BU improvement was similar among agents. Areas for future research include investigation of BU outcomes with other IBD therapies, exploration of underlying mechanisms of action, and greater standardisation for measuring BU through validated scores. |
| Systematic Review: Stigma Associated With Inflammatory Bowel Disease.
This highlights the heterogeneity in stigma assessment methods and the need for more standardised research. It also emphasises the importance of addressing stigma through increased awareness, support and interventions aimed at enhancing resilience and coping skills. |
| Waitlist and Post-Transplant Outcomes in Liver Transplantation for Alcohol-Associated Liver Disease: An Individual Patient Data Meta-Analysis.
In this reconstructed individual patient data meta-analysis, waitlist survival was comparable between ALD and non-ALD patients. While early post-transplant patient survival was similar, long-term survival remained inferior in ALD, partly attributed to increased de novo malignancy. These findings highlight the need for improved candidate selection, addiction care, and cancer surveillance to maximise long-term outcomes in the growing ALD transplant population. |
| Endoscopy |
| Environmental footprint of gastrointestinal endoscopy services: a systematic review.
- Current evidence on the environmental impact of GI endoscopy services is fragmented, methodologically inconsistent, and often limited in coverage. Emissions were dominated by patient travel, energy use and procedure-related products. Broader and more standardized environmental assessments are needed to guide the transition to low-carbon, sustainable GI endoscopy. . |
| Hepatology |
| Technical systematic review supporting 2025 AASLD Practice Guidelines on management of chronic hepatitis B.
Despite low certainty, the findings support shared decision-making in high-risk horizontal transmission scenarios or in treating individuals in the immune tolerance phase, caution in discontinuing antiviral therapy in virologically suppressed individuals without HBsAg loss, and tailored HCC surveillance for those with co-infection or cirrhosis. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Indocyanine Green Clearance Correlates With Biomarkers Reflecting Key Disease-Driving Mechanisms in Advanced Chronic Liver Disease and Predicts Acute-on-Chronic Liver Failure and Death.
ICG-R15 by PDD correlates with portal hypertension and systemic inflammation/circulatory dysfunction as key disease-driving mechanisms in ACLD. While showing insufficient discrimination for CSPH, ICG-R15 independently predicted ACLF/liver-related mortality in decompensated cirrhosis. |
| Very Early-Stage Detection Is Associated With Improved Survival in Patients With Unifocal Hepatocellular Carcinoma.
Detection of HCC at a T1a stage conveys a survival advantage compared to T1b stage, underscoring a continued need for improvements in HCC surveillance efficacy. |
| Am J Gastroenterol |
| Use of Natural language processing to objectively identify hepatic encephalopathy in multiple cohorts.
Five signs, symptoms, and treatment decisions with simple phrases extracted from inpatient charts using NLP define HE across three cohorts. This objectivity could aid future policy on LT priority and HE-event adjudication in clinical trials. |
| Clin Gastroenterol Hepatol |
| Acute severe ulcerative colitis patients from Asia have lower colectomy risk than patients from Australasia.
The characteristics of ASUC in Asia differ significantly from ANZ. Despite worse endoscopic severity and more extensive disease, the Asian ASUC cohort appears more corticosteroid responsive with significantly lower colectomy rates, with less requirement for advanced therapies. |
| Long-term disease course of Crohn's disease in a prospective European population-based inception cohort - an Epi-IBD cohort study.
Despite earlier and more frequent use of advanced therapies in Western Europe, no differences in disease outcomes were observed between Western and Eastern European patients. Ten years after diagnosis, one-in-five patients with uncomplicated disease at diagnosis progressed to complicated disease and one-in-four needed surgery. |
| Endoscopy |
| Gastric peroral endoscopic pyloromyotomy for refractory gastroparesis following esophagectomy: results from a multicenter series.
G-POEM appears to be a safe and effective treatment for refractory gastroparesis in post-esophagectomy patients, achieving significant symptom relief in the majority of patients. Future prospective studies are necessary to further validate these findings and explore predictive factors for treatment success. |
| Gastrointest Endosc |
| Clinical Outcomes of Endoscopic Papillectomy for Ampullary Adenoma and Adenocarcinoma: A Multicenter Retrospective Study in Japan.
Recurrence after EP for ampullary epithelial tumors is common, even after R0 resection. These findings highlight the need for long-term surveillance following EP. |
| Economic Impact and Utilization Trends of Peroral Endoscopic Myotomy and Endoscopic Submucosal Dissection.
While ESD and POEM may seem difficult to scale due to low reimbursement rates, this study demonstrates their substantial economic impact through significant downstream charges and reimbursements. These findings highlight the need to balance delivering accessible, affordable care with ensuring the financial sustainability of hospitals, especially as healthcare institutions face rising costs that are not always offset by reimbursement. |
| Outcomes of ERCP Performed Via a Lumen Apposing Gastroenterostomy Stent: A Multicenter Observational Study.
ERCP performed via a gastroenteric LAMS is safe and effective option for management of coincident GOO and biliary obstruction. |
| Required Withdrawal Times to Meet Adenoma Detection Targets During Colonoscopy.
Longer cWT improves detection across al metrics, with the greatest benefit for low performers. These results support implementation of individualized WT recommendations based on baseline endoscopist performance rather than a universal time threshold. |
| Gut |
| A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis.
Our findings elucidate a previously unrecognised A20-KEAP1-NRF2 axis that orchestrates hepatocyte ferroptosis in AIH. Targeting A20 may provide a promising therapeutic strategy for AIH. |
| Immune-related adverse events are a potent predictor of post-transplant rejection in HCC: a multicentre retrospective cohort study.
This study identified irAEs as a potent predictor of allograft rejection in HCC patients receiving pretransplant ICIs, potentially driven by heightened immune activation. The predictive model may help stratify patients at high risk of rejection. |
| Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study.
In this population, adding PegIFN-α2a increased HBsAg declines after reductions by JNJ-3989; 20.4% achieved HBsAg seroclearance at least once. Treatment was generally safe with acceptable tolerability. |
| Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy.
Background Human epidermal growth factor receptor 2 (HER2; . This information may guide trials combining trastuzumab or T-DXd with new agents to enhance the efficacy and durability of HER2 blockade. |
| Hepatology |
| Epigenetic repression of hepatocyte FoxO1 disrupts local immune homeostasis and promotes liver inflammation.
Our findings uncover a hitherto unrecognized mechanism for hepatocyte-based control of liver inflammation, in which hepatocyte FoxO1 maintained by JMJD1C restrains local NKT cells and neutrophils via CD1d induction, providing promising targets for inflammatory liver diseases. |
| KLF9 drives intermittent hypoxia-induced NAFLD by suppressing the NR4A1-p38 MAPK hepatic metabolic axis.
This study identifies KLF9 as a key transcriptional regulator driving IH-associated NAFLD by repressing NR4A1 and inhibiting p38 MAPK signaling, thereby promoting hepatic lipogenesis. Targeting the KLF9-NR4A1 axis may offer a novel therapeutic approach for managing NAFLD in patients with OSA and other hypoxia-related disorders. |
| Satellite lesions versus intrahepatic metastasis in multifocal intrahepatic cholangiocarcinoma: Prognostic impact and genomic profiling.
Multifocal ICC should be categorized as AJCC Stage III disease regardless of IM and SL patterns. Both SL and IM are clonal origin derived from primary ICC tumor, and represent metastatic progression with poor long-term survival. |
| J Hepatol |
| Predicting hepatic decompensation using non-invasive tests in a contemporary multicentre cohort of patients with cACLD.
In our multicentre study of contemporary European cACLD patients, non-invasively estimated CSPH risk was as predictive for decompensation as HVPG. Models comprising indicators of portal hypertension and albumin discriminated between patients at negligible decompensation risk and those with a 1-year risk of ≈15%, i.e., the potential target population for preventive strategies. Impact and implications Non-invasive tests (NITs) facilitate the early diagnosis and management of clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD) patients. In our contemporary cohort of cACLD patients with mainly steatotic liver disease recruited at 16 European expert centres, the hepatic venous pressure gradient (HVPG) and NITs were similarly predictive of decompensation within one to two years of follow-up. Serum albumin levels were identified as the second main predictor of decompensation besides the HVPG or NITs for CSPH. Novel models were developed that could accurately predict the risk for decompensation, thereby refining point-of-care risk stratification and clinical trial design in CTP-A cACLD patients. |
| Setd4-expressing cells drive regenerative recovery in chronic liver injury.
As a reserve population, dormant Setd4 + cells survive during chronic injury and then, beyond activation via chromatin remodelling, initiate de novo regeneration fundamental for recovery after chronic injury. Impact and implications This study reports a longevity population of dormant Setd4 + cell in the murine liver midlobular zone 2 that survive under chronic injury and then activate for facilitating regenerative recovery. As a reserve population, Setd4 + cells initiate de novo regeneration representing fundamental for chronic injury recovery via chromatin accessibility remodelling. Impact and implication Jia et al report a longevity population of dormant Setd4 + cell in the murine liver midlobular zone 2 that survive under chronic injury and then activate for facilitating regenerative recovery. As a reserve population, Setd4 + cells initiate de novo regeneration representing fundamental for chronic injury recovery via chromatin accessibility remodelling. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Editorial: When Yeast Turns Beast-Unmasking an Overlooked Threat in Alcohol-Related Hepatitis. |
| Gastroenterology |
| Too High, Just Right, or Not Enough? Rethinking AFP Thresholds for HCC Screening. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| 2025 CME Information. |
| Calendar of Courses, Symposiums and Conferences. |
| Endoscopy |
| A modified tetra-bite-on-bite biopsy technique under cholangioscopic guidance for biliary disease. |
| A novel absorbable string-loop suturing device for closing a large colonic defect spanning anastomosis after endoscopic submucosal dissection. |
| A pancreaticobiliary maljunction captured on video by peroral cholangioscopy. |
| A rare cause of partial small bowel obstruction. |
| A rescue technique for failed stent deployment by the stent-in-stent technique using mesh broken by holmium laser ablation. |
| Antegrade radial laser ablation for a pancreaticojejunal stricture under peroral pancreatoscopic guidance. |
| Appendiceal adenocarcinoma diagnosed by endoscopic retrograde appendicitis therapy - the first clinical experience. |
| Combination of underwater and traction-assisted endoscopic submucosal dissection: the perfect wedding for a challenging case. |
| Endoscopic closure after endoscopic submucosal dissection using novel hooking attachment with a knotting chain shaped thread system. |
| Endoscopic purse-string suture combined with metal clips for the closure of a large gastro-pleural fistula. |
| Endoscopic transpapillary gallbladder drainage for localized acute cholecystitis confined by segmental adenomyomatosis using a novel rotatable sphincterotome. |
| Endoscopic ultrasound-guided coil and Histoacryl therapy of varices at the hepaticojejunostomy. |
| Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of peritoneal tuberculosis. |
| Enhanced resection of exophytic gastric gastrointestinal stromal tumor using traction-assisted subserosal dissection and endoscopic suturing. |
| Enteroscopy-guided retrieval of a migrated gastric bypass stent from the mid-to-distal jejunum. |
| Redo per-oral endoscopic myotomy: direct septotomy and cardiomyotomy with mucosal closure via endoscopic hand suturing. |
| Removal of migrated pancreatic plastic stent by screw-type device under enteroscopy in pancreaticoduodenectomy. |
| Same-session endoscopic ultrasound-guided drainage and closure of a challenging peritoneal pseudocyst in a high-surgical-risk patient. |
| Successful diagnosis of intraductal mural nodule in non-dilated main pancreatic duct using novel ultrathin pancreatoscope. |
| Suture-and-clip continuous suturing technique: a novel endoscopic closure method for large mucosal defects. |
| Tip-in underwater endoscopic mucosal resection for a flat gastric tumor. |
| Underwater ultra-slim endoscopy for radiation-free intestinal stenting: overcoming difficult strictures. |
| Gastroenterology |
| An Unusual Cause of Hyperammonaemia and Acute Liver Failure in a Toddler. |
| Uncovering the Real Causes Behind Anemia. |
| Gastrointest Endosc |
| Endoscopic Resection of a Distal Bile Duct Adenoma Guided by EUS and ERCP (with video). |
| Transurethral ultrasound guided fine needle biopsy for diagnosis of recurrent rectal cancer. |
| Hepatology |
| Beyond AUROC: Critical evaluation of FSTL-1 as a liver fibrosis biomarker. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Editorial: When Yeast Turns Beast-Unmasking an Overlooked Threat in Alcohol-Related Hepatitis. Authors' Reply. |
| Letter: Antiviral Prophylaxis Mitigates HBV Reactivation Risk During Cancer Immunotherapy-Unresolved Challenges and Future Directions. |
| Letter: Antiviral Prophylaxis Mitigates HBV Reactivation Risk During Cancer Immunotherapy: Unresolved Challenges and Future Directions-Authors' Reply. |
| Letter: Optimizing Risk Stratification in Primary Biliary Cholangitis-The Role of Biochemical Response as a Dynamic Predictor. |
| Letter: Safety and Tolerability of Injectable Extended Release Naltrexone for the Management of Alcohol Use Disorder in Advanced Alcohol-Associated Liver Disease. |
| Letter: Safety and Tolerability of Injectable Extended-Release Naltrexone for the Management of Alcohol Use Disorder in Advanced Alcohol-Associated Liver Disease-Authors' Reply. |
| Clin Gastroenterol Hepatol |
| Upadacitinib Reinduction in IBD: Clarifying Steroid-Free Remission and Complementary Persistence Outcomes. |
| Gastroenterology |
| From Identification to Intervention: Advancing Ethical Governance for AI Bias in Gastroenterology. |
| Gene-Specific Adenoma Detection in Lynch Syndrome: Methodological Considerations and Clinical Implications. |
| Mechanistic Gaps and Therapeutic Promise in MASH-ATM sEV Research. |
| J Hepatol |
| Comment on: Nivolumab plus ipilimumab for potentially resectable hepatocellular carcinoma: long-term efficacy and biomarker exploration. |
| Hepatic LONP1 Overexpression Ameliorates Hepatic Steatosis and Fibrosis in mice. |